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Study of the effects of spinorphin on painful diabetic neuropathy: A behavioral study in vivo

Aim: Diabetic neuropathy is one of the chronic complications of diabetes. Our aim in this study is to examine the effects of spinorphine on painful diabetic neuropathy in vivo.  

Material and Methods: Seventy-five three-week rats were used. The first group was determined as a healthy control group (n = 15). Then, diabetic animals were grouped into subassemblies following induction in rats induced streptozotocin and diabetes. Groups were created using rat as follows: First group: Healthy control group, Second group: Diabetic control group (group to be given spinorphine solvent) (n = 15), Third group: DM + SP0.1 group (group to be applied 0.1 mg / kg spinorphine) (n = 15), Fourth Group: DM + SP1 group (group to be applied 1 mg / kg spinorphine) (n = 15) and Fifth group: DM + SP5 group (group to be applied 5 mg / kg spinorphine) (n = 15).

Results:  When the diabetic control group and the healthy control group were compared in terms of the pain threshold values, a statistically significant difference was found (P <0.05). This result was considered significant in regards to the development of neuropathy (P <0.05). The pain threshold values in DM + SP0.1 and DM + SP1 groups had no statistically significant differences compared with the diabetic control group (P> 0.05). 

Discussion: This study, found spinorphine to be effective at doses of 5mg/kg or higher and when administrated intraperitoneally in the acute antinociceptive treatment of painful neuropathy in diabetic rats.

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The effect of sufi music on sedation in patients under spinal anesthesia during orthopedic surgery

Aim: Music is the preferred method of sedation due to its noninvasive nature, affordable cost, and easy application. In this study, we aimed to compare music therapy with a control (non-music) group in terms of perioperative sedation requirements, anxiety levels, and patient satisfaction starting from the preoperative period in patients who underwent orthopedic surgery under spinal anesthesia.

Material and Methods: This study was carried out prospectively with 50 patients in the ASA I-II risk group, aged 18-60 years and will undergo elective non-oncological orthopedic surgery. Patients taken to the preparation room were randomly classified into two groups. Propofol (FRESENIUS-Germany) infusion was started at 1 mg/kg/hour in patients who underwent spinal anesthesia in the operation room. The Bispectral Index Monitor™ (BIS) was used to verify sedation. Hemodynamic data and BIS values were recorded preoperatively (t1) and during spinal anesthesia (t2). Perioperative values were recorded at the 5th, 15th, 30th, 60th minute (t3, t4, t5, t6) and postoperative 30th minute (t7).  

Results: There was no statistically significant difference between patients’ demographic characteristics and the duration of surgery. Although lower values were detected in the music group in terms of heart rate (HR) and mean arterial pressure (MAP) at all times, the difference between the groups was not statistically significant. When evaluated in terms of BIS scores, significantly lower values were recorded in the music group at all times. When Ramsey Sedation Scores were compared, while high scores were obtained at t2 and after in the music group at all times, the results at t5, t6, t7 times were found to be significantly higher.

Discussion: Our study showed that listening to Sufi music starting from the preoperative period has positive effects on anxiety. Considering the negative effects of anxiety on the experience of anesthesia and operation success, it can be said that the more frequent use of a non-invasive method such as music can reduce the anxiety of the operation.

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Opinions of patients related to radiology department during the COVID-19 pandemic

Aim: Patients experience tension due to the measures that should be taken against the COVID-19 pandemic in radiology departments. The objective of this study was to measure the opinions of patients related to the radiology department during the pandemic.

Material and Methods: The survey developed by the researcher in line with the current literature was applied to measure the satisfaction of patients in the radiology department. The survey consisted of 26 questions, the first six of which involved demographic characteristics. The survey was conducted with a face-to-face interview method.   

Results: The study included 300 patients referred to the radiology department due to any reason and who were voluntarily participated. The responders answered the questions that “Did you get information about your radiology examination before your appointment?” as “no” by 78%, “Did you have any questions to radiology department staff after your examinations?” as “yes” by 26% and “Did the staff of the radiology department and/or the radiologist take the time to answer your questions?” as “no” by 60.4%. The overall rate of satisfaction with the services delivered in the radiology department was found as 95%.

Discussion: Our survey shows that as high as 95% of the patients who were referred to the radiology department for imaging for any reason were satisfied with the radiology department during the pandemic. Such satisfaction surveys in departments such as radiology, where patients have limited access to staff, especially radiologists, provide valuable feedback to clinicians and other healthcare providers.


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